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Initialized Capital Backing founders obsessed with hard problems. Early investors in Coinbase, Instacart, Rippling, Flexport, Flock, TRM, Valar Atomics + more.

10/15/2026

What makes Very Low Earth Orbit (VLEO) so compelling…and so difficult to operate in?

Albedo’s AyJay Lasater joins High Bit to explain the challenges of VLEO, from atmospheric drag and short satellite lifetimes to the engineering needed to make it work.

Albedo’s goal: Bringing space closer to Earth for all mission needs and all mission scenarios.

Full episode at the link in bio.

10/08/2026

Set up a tripod with a camera and run away. It finds the sun and calibrates itself.

On High Bit, Picogrid’s Zane Mountcastle explains how the team is building systems that can calibrate and connect quickly in GPS-denied environments.

Full episode at the link in bio.

09/03/2026

Clone is building robots more like humans, starting with the muscles.

On High Bit, cofounder & CEO Dhanush Radhakrishnan explains how artificial muscles attached at anatomically accurate points can simplify robot design and enable human-level movement.

Full convo at the link in bio.

We’re proud to support Outer Biosciences as they emerged from stealth recently. Co-founded by Michael Polansky, Outer Bi...
08/31/2026

We’re proud to support Outer Biosciences as they emerged from stealth recently. Co-founded by Michael Polansky, Outer Bio grew out of a frustration with how slowly innovation in biology and chemistry can move, in part because researchers can’t simply test new ideas directly on people.

That challenge is especially clear in skin health, where human skin outside the body typically stays usable for only about a week. But many of the biological processes researchers want to understand, from collagen remodeling and pigmentation changes to inflammation and barrier repair, take weeks to unfold.

Yuna is Outer Bio’s answer to that. The team sources human skin that would otherwise be discarded after surgery and has developed a way to keep living, full-thickness tissue viable and observable for four weeks.

Yuna also pairs those experiments with machine learning trained on Outer Bio’s own tissue data, creating a closed loop where each experiment helps sharpen the next prediction.

07/30/2026

Reliable AI interpretability has to be built into the training process, not added afterward. Much of the field works the other way around: train the model first, then try to explain what billions of parameters learned.

Guide Labs is taking a different approach, building diffusion language models designed to trace outputs back to their context, the concepts influencing them, and the training data behind them.

On the new episode of High Bit, cofounder and CEO Julius Adebayo explains how his PhD research challenged the assumption that interpretability comes at the cost of performance:
“You can train these big neural networks, constrain them while you’re training them, and still have them match the performance of something that was not constrained ahead of time.”

Full episode linked in bio.

07/28/2026

Founders are often working around the clock, through weekends and summer breaks.

Every now and then you need to take a break from the grind and enjoy the rare hot summer days in San Francisco. We loved hosting our founder community (and their plus 1s!) at a casual BBQ and game night in our SF office space.

It was especially fun to see everyone’s competitive sides come out over intense games of Uno, Mahjong, and Liar’s Dice. Careful who you Uno reverse, much yelling may ensue.

07/14/2026

Greptile’s Daksh Gupta at High Bit Live talking about a new class of engineers: new grads who learned to code with AI from the start.

Watch the full convo with Daksh, Trunk.io’s Matt Matheson, and Initialized’s Brett Gibson at the link in our bio.

07/10/2026

Matt Matheson of Trunk.io on the two engineer archetypes he thinks become especially valuable as AI takes on more generalist work: deep subject matter experts + creative builders who can take an idea all the way to customers.

Full episode of High Bit Live at the link in bio.

07/07/2026

Tune in to our first-ever live recording of High Bit with Initialized’s Brett Gibson, Greptile’s Daksh Gupta, and Trunk.io’s Matt Matheson.

The trio dig into building at the center of the AI engineering shift — what happens when teams ship faster than their review and testing processes can keep up, rethinking team size and autonomy, and more. Link in bio.

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